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Mouse Anti-UBE2I Recombinant Antibody (67AT1273.95.90) (CBMAB-U0115-FY)

This product is mouse antibody that recognizes UBE2I. The antibody 67AT1273.95.90 can be used for immunoassay techniques such as: ELISA, WB.
See all UBE2I antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
67AT1273.95.90
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
GST-UBC9 fusion protein
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ubiquitin Conjugating Enzyme E2 I
Introduction
Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. Can catalyze the formation of poly-SUMO chains.
Entrez Gene ID
Human7329
Mouse22196
Rat25573
UniProt ID
HumanP63279
MouseP63280
RatP63281
Alternative Names
P18; UBC9; C358B7.1
Function
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (PubMed:26620705).
Biological Process
Biological Process cell division Source:UniProtKB-KW
Biological Process chromosome segregation Source:UniProtKB-KW
Biological Process mitotic nuclear membrane reassembly Source:Reactome
Biological Process negative regulation of DNA-templated transcription Source:BHF-UCL1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process nuclear export Source:ComplexPortal1 Publication
Biological Process positive regulation of cell migration Source:BHF-UCL1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:Ensembl
Biological Process positive regulation of SUMO transferase activity Source:BHF-UCL1 Publication
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process protein sumoylation Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:ProtInc1 Publication
Cellular Location
Nucleus
Cytoplasm
Cytoplasm, perinuclear region
Mainly nuclear (By similarity).
In spermatocytes, localizes in synaptonemal complexes (PubMed:8610150).
Recruited by BCL11A into the nuclear body (By similarity).
PTM
Phosphorylation at Ser-71 significantly enhances SUMOylation activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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