ZNF335

The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure.

Full Name

zinc finger protein 335

Function

Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126).
Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338).
Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126).
Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126).

Biological Process

Biological Process brain development Source:UniProtKB1 Publication
Biological Process brain morphogenesis Source:Ensembl
Biological Process cerebral cortex neuron differentiation Source:Ensembl
Biological Process epigenetic regulation of gene expression Source:UniProtKB1 Publication
Biological Process histone H3-K4 trimethylation Source:GO_Central1 Publication
Biological Process in utero embryonic development Source:Ensembl
Biological Process neuron projection morphogenesis Source:UniProtKB
Biological Process positive regulation of lymphocyte proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of neuroblast proliferation Source:UniProtKB
Biological Process positive regulation of neurogenesis Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of histone H3-K4 methylation Source:GO_Central1 Publication

Cellular Location

Nucleus

Involvement in disease

Microcephaly 10, primary, autosomal recessive (MCPH10):
A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH10 is characterized by extremely small head size and death usually by 1 year of age. Neuropathologic examination shows severe loss of neurons as well as neuronal loss of polarity and abnormal dendritic maturation.