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Mouse Anti-ZNF335 Recombinant Antibody (2C1) (CBMAB-0845-LY)

This product is mouse antibody recognizes ZNF335 of human. The antibody 2C1 immunoassay techniques such as: IP, MA, WB.
See all ZNF335 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C1
Antibody Isotype
IgG2c
Application
IP, MA, WB

Basic Information

Immunogen
Recombinant peptide (aa 180-195)
Specificity
Human
Antibody Isotype
IgG2c
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
zinc finger protein 335
Introduction
The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.
Entrez Gene ID
63925
UniProt ID
Q9H4Z2
Alternative Names
bA465L10.2; NIF-1
Function
Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126).
Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338).
Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126).
Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126).
Biological Process
Biological Process brain development Source:UniProtKB1 Publication
Biological Process brain morphogenesis Source:Ensembl
Biological Process cerebral cortex neuron differentiation Source:Ensembl
Biological Process epigenetic regulation of gene expression Source:UniProtKB1 Publication
Biological Process histone H3-K4 trimethylation Source:GO_Central1 Publication
Biological Process in utero embryonic development Source:Ensembl
Biological Process neuron projection morphogenesis Source:UniProtKB
Biological Process positive regulation of lymphocyte proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of neuroblast proliferation Source:UniProtKB
Biological Process positive regulation of neurogenesis Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of histone H3-K4 methylation Source:GO_Central1 Publication
Cellular Location
Nucleus
Involvement in disease
Microcephaly 10, primary, autosomal recessive (MCPH10):
A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH10 is characterized by extremely small head size and death usually by 1 year of age. Neuropathologic examination shows severe loss of neurons as well as neuronal loss of polarity and abnormal dendritic maturation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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