ADCYAP1R1

Adcyap1r1 is type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.

ADCYAP Receptor Type I

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

Adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Cell differentiation
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Multicellular organism development
Negative regulation of inflammatory response to antigenic stimulus
Spermatogenesis

Cell membrane

Extracellular: 21-155 aa
Helical: 156-178 aa
Cytoplasmic: 179-186 aa
Helical: 187-205 aa
Extracellular: 206-227 aa
Helical: 228-253 aa
Cytoplasmic: 254-268 aa
Helical: 269-291 aa
Extracellular: 292-309 aa
Helical: 310-332 aa
Cytoplasmic: 333-350 aa
Helical: 351-371 aa
Extracellular: 372-385 aa
Helical: 386-405 aa
Cytoplasmic: 406-468 aa