BACH2

Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity).

BACH2

Transcriptional regulator that acts as repressor or activator (By similarity).
Binds to Maf recognition elements (MARE) (By similarity).
Plays an important role in coordinating transcription activation and repression by MAFK (By similarity).
Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862).
Positively regulates the nuclear import of actin (By similarity).
Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713).

Import into nucleus Source: UniProtKB
Primary adaptive immune response involving T cells and B cells Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Nucleus; Cytoplasm. Nucleocytoplasmic shuttling is controlled by phosphorylation.

Immunodeficiency 60 (IMD60): An autosomal dominant primary immunologic disorder characterized by intestinal inflammation, recurrent sino-pulmonary infections, impaired lymphocyte maturation, and variably decreased immunoglobulin production.

Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export.
The reversible disulfide bond may provide a mechanism to regulate the activity in oxidative stress responses.