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Rabbit Anti-BACH2 Recombinant Antibody (D3T3G) (CBMAB-0147-YC)

Provided herein are mouse monoclonal antibodies against Human BACH2. The antibody clone 2C5 can be used for immunoassay techniques, such as IP and MA.
See all BACH2 antibodies
Published Data
Rabbit Anti-BACH2 Recombinant Antibody (D3T3G) in WB
Western blot for indicated proteins of total lysates isolated from the clonally derived inducible-BACH2 and control reporter cell lines with or without tetracycline treatment. ...View More
Vardaka, P., Lozano, T., Bot, C., Ellery, J., Whiteside, S. K., Imianowski, C. J., ... & Roychoudhuri, R. (2020). A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2. Scientific Reports, 10(1), 18902.

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D3T3G
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues surrounding Ala304 of human BACH2 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IP1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BACH2
Introduction
Transcription regulator protein BACH2 is a protein that in humans is encoded by the BACH2 gene. It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer and a bZip_Maf domain at the C-terminus.
Entrez Gene ID
60468
UniProt ID
Q9BYV9
Alternative Names
BTBD25
Function
Transcriptional regulator that acts as repressor or activator (By similarity).
Binds to Maf recognition elements (MARE) (By similarity).
Plays an important role in coordinating transcription activation and repression by MAFK (By similarity).
Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862).
Positively regulates the nuclear import of actin (By similarity).
Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713).
Biological Process
Import into nucleus Source: UniProtKB
Primary adaptive immune response involving T cells and B cells Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus; Cytoplasm. Nucleocytoplasmic shuttling is controlled by phosphorylation.
Involvement in disease
Immunodeficiency 60 (IMD60): An autosomal dominant primary immunologic disorder characterized by intestinal inflammation, recurrent sino-pulmonary infections, impaired lymphocyte maturation, and variably decreased immunoglobulin production.
PTM
Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export.
The reversible disulfide bond may provide a mechanism to regulate the activity in oxidative stress responses.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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