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Mouse Anti-BACH2 Recombinant Antibody (CBYY-0135) (CBMAB-0136-YY)

This product is mouse antibody that recognizes BACH2. The antibody CBYY-0135 can be used for immunoassay techniques such as: IP
See all BACH2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-0135
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
Human BACH2 recombinant protein (513-841 a.a.) expressed in E. coli.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB0.1-1 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% sodium azide
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BACH2
Introduction
Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity).
Entrez Gene ID
60468
UniProt ID
Q9BYV9
Alternative Names
BTB Domain And CNC Homolog 2; BTB And CNC Homology 1, Basic Leucine Zipper Transcription Factor 2; BTB And CNC Homolog 2; Transcription Regulator Protein BACH2; BTBD25;
Function
Transcriptional regulator that acts as repressor or activator (By similarity).
Binds to Maf recognition elements (MARE) (By similarity).
Plays an important role in coordinating transcription activation and repression by MAFK (By similarity).
Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862).
Positively regulates the nuclear import of actin (By similarity).
Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713).
Biological Process
Import into nucleus Source: UniProtKB
Primary adaptive immune response involving T cells and B cells Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus; Cytoplasm. Nucleocytoplasmic shuttling is controlled by phosphorylation.
Involvement in disease
Immunodeficiency 60 (IMD60): An autosomal dominant primary immunologic disorder characterized by intestinal inflammation, recurrent sino-pulmonary infections, impaired lymphocyte maturation, and variably decreased immunoglobulin production.
PTM
Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export.
The reversible disulfide bond may provide a mechanism to regulate the activity in oxidative stress responses.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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