C8A

Full Name

complement C8 alpha chain

Function

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.

Biological Process

Complement activation Source: MGI
Complement activation, alternative pathway Source: UniProtKB-KW
Complement activation, classical pathway Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Immune response Source: ProtInc
Regulation of complement activation Source: Reactome

Cellular Location

Cell membrane; Secreted. Secreted as soluble protein. Inserts into the cell membrane of target cells.

Involvement in disease

Complement component 8 deficiency, 1 (C8D1): A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

Anti-C8A antibodies

Mouse Anti-C8a Recombinant Antibody (CBXC-0028) (CBMAB-C5948-CQ)

Datasheet

SDS

Target: C8A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0028

Application*: E, F, IH, WB

Mouse Anti-C8A Recombinant Antibody (056B-373) (CBMAB-C1792-LY)

Datasheet

SDS

Target: C8A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 056B-373

Application*: WB, E, C, F

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)