CAR2

The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene.

CARBONIC ANHYDRASE 2

Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.

Angiotensin-activated signaling pathway Source: UniProtKB
Carbon dioxide transport Source: MGI
Cellular response to fluid shear stress Source: Ensembl
Kidney development Source: Ensembl
Morphogenesis of an epithelium Source: MGI
Odontogenesis of dentin-containing tooth Source: Ensembl
One-carbon metabolic process Source: GO_Central
Positive regulation of bone resorption Source: MGI
Positive regulation of cellular pH reduction Source: MGI
Positive regulation of dipeptide transmembrane transport Source: UniProtKB
Positive regulation of osteoclast differentiation Source: MGI
Positive regulation of synaptic transmission, GABAergic Source: MGI
Regulation of anion transport Source: UniProtKB
Regulation of chloride transport Source: MGI
Regulation of intracellular pH Source: UniProtKB
Regulation of pH Source: MGI
Response to estrogen Source: Ensembl
Response to pH Source: Ensembl
Response to steroid hormone Source: Ensembl
Response to zinc ion Source: Ensembl
Secretion Source: MGI

Cytoplasm; Cell membrane. Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells (By similarity).