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Rabbit Anti-CAR2 Recombinant Antibody (CBFYC-0809) (CBMAB-C0864-FY)

This product is rabbit antibody that recognizes CAR2. The antibody CBFYC-0809 can be used for immunoassay techniques such as: ELISA.
See all CAR2 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBFYC-0809
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Mouse Carbonic Anhydrase II/CA2 protein
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CARBONIC ANHYDRASE 2
Introduction
The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
12349
UniProt ID
P00920
Alternative Names
Ca2; CAII; Car-2; Ltw-5; Lvtw-5; AI131712
Function
Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.
Biological Process
Angiotensin-activated signaling pathway Source: UniProtKB
Carbon dioxide transport Source: MGI
Cellular response to fluid shear stress Source: Ensembl
Kidney development Source: Ensembl
Morphogenesis of an epithelium Source: MGI
Odontogenesis of dentin-containing tooth Source: Ensembl
One-carbon metabolic process Source: GO_Central
Positive regulation of bone resorption Source: MGI
Positive regulation of cellular pH reduction Source: MGI
Positive regulation of dipeptide transmembrane transport Source: UniProtKB
Positive regulation of osteoclast differentiation Source: MGI
Positive regulation of synaptic transmission, GABAergic Source: MGI
Regulation of anion transport Source: UniProtKB
Regulation of chloride transport Source: MGI
Regulation of intracellular pH Source: UniProtKB
Regulation of pH Source: MGI
Response to estrogen Source: Ensembl
Response to pH Source: Ensembl
Response to steroid hormone Source: Ensembl
Response to zinc ion Source: Ensembl
Secretion Source: MGI
Cellular Location
Cytoplasm; Cell membrane. Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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