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CFP

This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]

Full Name

Complement Factor Properdin

Function

A positive regulator of the alternate pathway (AP) of complement (PubMed:20382442, PubMed:28264884).
It binds to and stabilizes the C3- and C5-convertase enzyme complexes (PubMed:20382442, PubMed:28264884).
Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (PubMed:31507604).

Biological Process

Complement activation Source: Reactome
Complement activation, alternative pathway Source: Reactome
Defense response to bacterium Source: ProtInc
Immune response Source: ProtInc
Neutrophil degranulation Source: Reactome
Regulation of complement activation Source: Reactome

Cellular Location

Secreted

Involvement in disease

Properdin deficiency (PFD): Results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III).

Anti-CFP antibodies

Mouse Anti-CFP Recombinant Antibody (10C5) (CBMAB-C0174-LY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 10C5

Application*: E, WB

Mouse Anti-CFP Recombinant Antibody (01-10-18) (CBMAB-C1603-LY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 01-10-18

Application*: C, IA, FN

Mouse Anti-CFP Recombinant Antibody (10-18) (CBMAB-C2035-LY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10-18

Application*: E, FN, C

Mouse Anti-CFP Recombinant Antibody (10-24) (CBMAB-C2045-LY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10-24

Application*: E, C

Mouse Anti-CFP Recombinant Antibody (10B2571) (CBMAB-C2198-LY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10B2571

Application*: E, IH

Mouse Anti-CFP Recombinant Antibody (39739) (CBMAB-C5614-LY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 39739

Application*: E, FN, IH, C

Mouse Anti-CFP Recombinant Antibody (6F180) (CBMAB-C8265-LY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 6F180

Application*: E, WB

Mouse Anti-CFP Recombinant Antibody (CBFYC-0195) (CBMAB-C0220-FY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYC-0195

Application*: E, WB

Mouse Anti-CFP Recombinant Antibody (CBFYC-1774) (CBMAB-C1836-FY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1774

Application*: C, E, FN

Mouse Anti-CFP Recombinant Antibody (CBFYC-1775) (CBMAB-C1837-FY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1775

Application*: E, FN, C

Mouse Anti-CFP Recombinant Antibody (SIM295-9.3.4) (CBMAB-P0224-YC)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: SIM295-9.3.4

Application*: E, F, IH, WB

Mouse Anti-CFP Recombinant Antibody (CBWJC-2543) (CBMAB-C3623WJ)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJC-2543

Application*: E

Mouse Anti-CFP Recombinant Antibody (CBWJC-2544) (CBMAB-C3624WJ)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJC-2544

Application*: WB, E, IH, DB

Mouse Anti-CFP Recombinant Antibody (CBWJC-2545) (CBMAB-C3625WJ)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJC-2545

Application*: E, DB, WB, IP

Recombinant Armenian hamster Anti-CFP Antibody (CBHb109) (CBMAB-Hb890-LY)

SDS

Target: CFP

Host: Armenian hamster

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBHb109

Application*: FuncS, Immuno assays, WB

Recombinant Mouse Anti-CFP Antibody (CBHb302) (CBMAB-Hb892-LY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBHb302

Application*: Immuno assays

Recombinant Mouse Anti-CFP Antibody (CBHb303) (CBMAB-Hb893-LY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBHb303

Application*: FC, IHC-F, Immuno assays, WB

Recombinant Mouse Anti-CFP Antibody (CBHb357) (CBMAB-Hb344-LY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBHb357

Application*: FuncS, Immuno assays, WB

Recombinant Mouse Anti-CFP Antibody (CBHb358) (CBMAB-Hb345-LY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rabbit

Clone: CBHb358

Application*: FuncS, Immuno assays, WB

Mouse Anti-CFP Recombinant Antibody (I8/1) (CBMAB-AO304LY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: I8/1

Application*: ELISA, WB

Mouse Anti-CFP Recombinant Antibody (D10/4) (CBMAB-AO305LY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: D10/4

Application*: ELISA, WB

Mouse Anti-CFP Recombinant Antibody (CBFYA-0200) (CBMAB-X0283-FY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYA-0200

Application*: IA

Mouse Anti-CFP Recombinant Antibody (3A3E1) (CBMAB-X0346-FY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rabbit

Clone: 3A3E1

Application*: FN, IA, WB

Mouse Anti-CFP Recombinant Antibody (SIM 295-9.3.4) (CBMAB-X0401-FY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: SIM 295-9.3.4

Application*: F, C, IA, WB

Mouse Anti-CFP Recombinant Antibody (39745) (CBMAB-C5615-LY)

SDS

Target: CFP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 39745

Application*: E, IH, C

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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