CHRM4

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]

Cholinergic Receptor Muscarinic 4

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.

Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway Source: GO_Central
Cell surface receptor signaling pathway Source: ProtInc
Chemical synaptic transmission Source: GO_Central
G protein-coupled acetylcholine receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Regulation of locomotion Source: InterPro
Signal transduction Source: ProtInc

Cell membrane; Postsynaptic cell membrane

Extracellular: 1-31
Helical: 32-54
Cytoplasmic: 55-68
Helical: 69-89
Extracellular: 90-106
Helical: 107-128
Cytoplasmic: 129-148
Helical: 149-171
Extracellular: 172-193
Helical: 194-216
Cytoplasmic: 217-401
Helical: 402-422
Extracellular: 423-436
Helical: 437-456
Cytoplasmic: 457-479