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Rabbit Anti-CHRM4 Recombinant Antibody (EG683) (CBMAB-EN824-LY)

The product is antibody recognizes CHRM4. The antibody EG683 immunoassay techniques such as: IF: 1:100~1:500 ELISA: 1:10000.
See all CHRM4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG683
Antibody Isotype
IgG
Application
IF: 1:100~1:500 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human CHRM4.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cholinergic Receptor Muscarinic 4
Introduction
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human1132
Mouse12672
Rat25111
UniProt ID
HumanP08173
MouseP32211
RatP08485
Alternative Names
Cholinergic Receptor Muscarinic 4; Acetylcholine Receptor, Muscarinic 4; Muscarinic Acetylcholine Receptor M4; HM4; M4R;
Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway Source: GO_Central
Cell surface receptor signaling pathway Source: ProtInc
Chemical synaptic transmission Source: GO_Central
G protein-coupled acetylcholine receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Regulation of locomotion Source: InterPro
Signal transduction Source: ProtInc
Cellular Location
Cell membrane; Postsynaptic cell membrane
Topology
Extracellular: 1-31
Helical: 32-54
Cytoplasmic: 55-68
Helical: 69-89
Extracellular: 90-106
Helical: 107-128
Cytoplasmic: 129-148
Helical: 149-171
Extracellular: 172-193
Helical: 194-216
Cytoplasmic: 217-401
Helical: 402-422
Extracellular: 423-436
Helical: 437-456
Cytoplasmic: 457-479
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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