CHST9

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2011]

Carbohydrate Sulfotransferase 9

Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.

Carbohydrate biosynthetic process Source: InterPro
Chondroitin sulfate biosynthetic process Source: Reactome
Glycosaminoglycan metabolic process Source: UniProtKB
Hormone biosynthetic process Source: UniProtKB
Proteoglycan biosynthetic process Source: UniProtKB
Sulfur compound metabolic process Source: UniProtKB

Isoform 1: Golgi apparatus membrane
Isoform 2: Secreted

Cytoplasmic: 1-12
Helical: 13-33
Lumenal: 34-443