Rabbit Anti-CHST9 Recombinant Antibody (EG689) (CBMAB-EN830-LY)

The product is antibody recognizes CHST9. The antibody EG689 immunoassay techniques such as: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:40000.
See all CHST9 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse

Clone

EG689

Antibody Isotype

IgG

Application

IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:40000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human CHST9.

Specificity

Human, Mouse

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Carbohydrate Sulfotransferase 9

Introduction

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2011]

Entrez Gene ID

Human	83539
Mouse	71367

UniProt ID

Human	Q7L1S5
Mouse	Q76EC5

Alternative Names

Carbohydrate Sulfotransferase 9; Carbohydrate (N-Acetylgalactosamine 4-0) Sulfotransferase 9; GalNAc-4-O-Sulfotransferase 2; GALNAC4ST-2; N-Acetylgalactosamine 4-O-Sulfotransferase 2; N-Acetylgalactosamine-4-O-Sulfotransferase 2;

Function

Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.

Biological Process

Carbohydrate biosynthetic process Source: InterPro
Chondroitin sulfate biosynthetic process Source: Reactome
Glycosaminoglycan metabolic process Source: UniProtKB
Hormone biosynthetic process Source: UniProtKB
Proteoglycan biosynthetic process Source: UniProtKB
Sulfur compound metabolic process Source: UniProtKB

Cellular Location

Isoform 1: Golgi apparatus membrane
Isoform 2: Secreted

Topology

Cytoplasmic: 1-12
Helical: 13-33
Lumenal: 34-443

References

Dzhambetova, P. M., Bisultanova, Z. I., & Atsaeva, M. M. (2021, December). Genetic variant CHST9 Rs1436904 in breast cancer prognosis. In AIP Conference Proceedings (Vol. 2442, No. 1, p. 030004). AIP Publishing LLC.

Chen, J., Wu, J. S., Mize, T., Moreno, M., Hamid, M., Servin, F., ... & Chen, X. (2019). A frameshift variant in the CHST9 gene identified by family-based whole genome sequencing is associated with schizophrenia in Chinese population. Scientific reports, 9(1), 1-9.

Sharp, C., Chen, J., Moreno, M., Hamid, M., Servin, F., Bashy, B., & Mize, T. (2018). Identification of CHST9 as A Candidate Gene for Schizophrenia from Whole Genome Sequencing.

Yuan, J., Zhang, N., Zhu, H., Liu, J., Xing, H., Ma, F., & Yang, M. (2017). CHST9 rs1436904 genetic variant contributes to prognosis of triple-negative breast cancer. Scientific reports, 7(1), 1-8.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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