CLIC4

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]

Chloride Intracellular Channel 4

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).

Angiogenesis Source: GO_Central
Branching morphogenesis of an epithelial tube Source: Ensembl
Cell differentiation Source: UniProtKB
Cellular response to calcium ion Source: UniProtKB
Chloride transport Source: UniProtKB
Endothelial cell morphogenesis Source: Ensembl
Establishment or maintenance of apical/basal cell polarity Source: UniProtKB
Fertilization Source: Ensembl
Keratinocyte differentiation Source: UniProtKB
Multicellular organism growth Source: Ensembl
Negative regulation of cell migration Source: UniProtKB
Regulation of cytoskeleton organization Source: UniProtKB
Regulation of ion transmembrane transport Source: UniProtKB-KW
Retina vasculature morphogenesis in camera-type eye Source: Ensembl
Vacuolar acidification Source: Ensembl

Cell membrane; Nucleus matrix; Centrosome; Mitochondrion; Cytoplasmic vesicle membrane; Cell junction. Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.

Helical: 37-57