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CLPP

The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]

Full Name

Caseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit

Function

Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (PubMed:11923310, PubMed:15522782).

Cleaves PINK1 in the mitochondrion (PubMed:22354088).

Biological Process

Membrane protein proteolysis Source: UniProtKB
Protein quality control for misfolded or incompletely synthesized proteins Source: GO_Central
Proteolysis involved in cellular protein catabolic process Source: UniProtKB

Cellular Location

Mitochondrion matrix

Involvement in disease

Perrault syndrome 3 (PRLTS3):
A sex-influenced disorder characterized by sensorineural deafness in both males and females, and ovarian dysgenesis in females. Affected females have primary amenorrhea, streak gonads, and infertility, whereas affected males show normal pubertal development and are fertile. A spectrum of additional clinical features, including cerebellar ataxia, learning disability, and peripheral neuropathy, have been described in some PRLTS3 affected individuals.

Anti-CLPP antibodies

Mouse Anti-CLPP Recombinant Antibody (2E1D9) (CBMAB-C4972-LY)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human, Pig

Clone: 2E1D9

Application*: E, C, WB

Mouse Anti-CLPP Recombinant Antibody (1E2) (CBMAB-C3925-LY)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Dog, Human, Monkey

Clone: 1E2

Application*: WB, F

Rabbit Anti-CLPP Recombinant Antibody (CBWJC-2821) (CBMAB-C3938WJ)

SDS

Target: CLPP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBWJC-2821

Application*: WB, IP, F

Mouse Anti-CLPP Recombinant Antibody (CBWJC-2820) (CBMAB-C3937WJ)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Rat, Monkey

Clone: CBWJC-2820

Application*: WB, IH, IF, F

Mouse Anti-CLPP Recombinant Antibody (CBWJC-2819) (CBMAB-C3936WJ)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: CBWJC-2819

Application*: WB, IF, F

Mouse Anti-CLPP Recombinant Antibody (CBXC-2740) (CBMAB-C5418-CQ)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human, Pig

Clone: CBXC-2740

Application*: E, IH, WB

Mouse Anti-CLPP Recombinant Antibody (CBXC-1953) (CBMAB-C5417-CQ)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Dog, Rat, Monkey

Clone: CBXC-1953

Application*: WB, IF, F

Mouse Anti-CLPP Recombinant Antibody (CBXC-1963) (CBMAB-C5416-CQ)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Dog, Rat, Monkey

Clone: CBXC-1963

Application*: WB, IF, F

Mouse Anti-CLPP Recombinant Antibody (CBXC-1944) (CBMAB-C5414-CQ)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-1944

Application*: WB, IH, F

Mouse Anti-CLPP Recombinant Antibody (CBFYC-1958) (CBMAB-C2024-FY)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1958

Application*: F, IF, P, WB

Mouse Anti-CLPP Recombinant Antibody (CBFYC-1957) (CBMAB-C2023-FY)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYC-1957

Application*: F, IF, WB

Mouse Anti-CLPP Recombinant Antibody (CBFYC-1956) (CBMAB-C2022-FY)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1956

Application*: F, IH, WB

Mouse Anti-CLPP (AA 178-278) Recombinant Antibody (CBFYC-1955) (CBMAB-C2021-FY)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-1955

Application*: E, WB

Mouse Anti-CLPP Recombinant Antibody (CBFYC-1954) (CBMAB-C2020-FY)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Dog, Mouse, Rat

Clone: CBFYC-1954

Application*: F, IF, WB

Mouse Anti-CLPP Recombinant Antibody (555) (CBMAB-AP1549LY)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human

Clone: 555

Application*: ELISA, IHC, WB

Mouse Anti-CLPP Recombinant Antibody (CBCNC-027) (CBMAB-C0920-CN)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBCNC-027

Application*: E, WB

Mouse Anti-CLPP Recombinant Antibody (CBWJC-2817) (CBMAB-C3934WJ)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBWJC-2817

Application*: E, WB

Mouse Anti-CLPP Recombinant Antibody (3E2) (CBMAB-C5945-LY)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3E2

Application*: E, P, WB

Mouse Anti-CLPP Recombinant Antibody (1G9) (CBMAB-C4210-LY)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1G9

Application*: F, P, WB

Mouse Anti-CLPP Recombinant Antibody (1F6) (CBMAB-C4069-LY)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat, Dog

Clone: 1F6

Application*: WB, F, IH, IC/IF, P

Mouse Anti-CLPP Recombinant Antibody (1E8) (CBMAB-C3980-LY)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1E8

Application*: F, IF, WB

Mouse Anti-CLPP Recombinant Antibody (1D8) (CBMAB-C3873-LY)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 1D8

Application*: F, IF, WB

Mouse Anti-CLPP Recombinant Antibody (1C7) (CBMAB-C3769-LY)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1C7

Application*: F, C, WB

Mouse Anti-CLPP Recombinant Antibody (10B2264) (CBMAB-C2177-LY)

SDS

Target: CLPP

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 10B2264

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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