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Mouse Anti-CLPP Recombinant Antibody (CBXC-1963) (CBMAB-C5416-CQ)

This product is a mouse antibody that recognizes CLPP. The antibody CBXC-1963 can be used for immunoassay techniques such as: WB, IF, FC.
See all CLPP antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Rat, Monkey
Clone
CBXC-1963
Antibody Isotype
IgG2a
Application
WB, IF, FC

Basic Information

Immunogen
Full length human recombinant protein of human CLPP (NP_006003)
Specificity
Human, Dog, Rat, Monkey
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Caseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit
Introduction
The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane.
Entrez Gene ID
Human8192
Dog611738
Rat301117
Monkey699593
UniProt ID
HumanQ16740
DogE2QUV8
RatM0RAD5
MonekyA0A0D9RBE5
Alternative Names
Caseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit; Endopeptidase Clp; EC 3.4.21.92; ClpP (Caseinolytic Protease, ATP-Dependent, Proteolytic Subunit, E. Coli) Homolog; ClpP Caseinolytic Peptidase, ATP-Dependent, Proteolytic Subunit Homolog (E. Coli); ClpP Caseinolytic Protease, ATP-Dependent, Proteolytic Subunit Homolog (E. Coli); ClpP Caseinolytic Peptidase, ATP-Dependent, Proteolytic Subunit Homolog; ClpP Caseinolytic Protease, ATP-Dependent, Proteolytic Subunit Homolog;
Function
Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (PubMed:11923310, PubMed:15522782).

Cleaves PINK1 in the mitochondrion (PubMed:22354088).
Biological Process
Membrane protein proteolysis Source: UniProtKB
Protein quality control for misfolded or incompletely synthesized proteins Source: GO_Central
Proteolysis involved in cellular protein catabolic process Source: UniProtKB
Cellular Location
Mitochondrion matrix
Involvement in disease
Perrault syndrome 3 (PRLTS3):
A sex-influenced disorder characterized by sensorineural deafness in both males and females, and ovarian dysgenesis in females. Affected females have primary amenorrhea, streak gonads, and infertility, whereas affected males show normal pubertal development and are fertile. A spectrum of additional clinical features, including cerebellar ataxia, learning disability, and peripheral neuropathy, have been described in some PRLTS3 affected individuals.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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