COX7A1

COX7A1 (Cytochrome C Oxidase Subunit 7A1) is a Protein Coding gene.

Cytochrome C Oxidase Subunit 7A1

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Generation of precursor metabolites and energy Source: ProtInc
Mitochondrial respirasome assembly Source: GO_Central
Oxidative phosphorylation Source: UniProtKB-UniPathway
Regulation of oxidative phosphorylation Source: GO_Central

Mitochondrion inner membrane

Mitochondrial matrix: 22-46
Helical: 47-75
Mitochondrial intermembrane: 76-79