CREM

This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq]

CAMP Responsive Element Modulator

Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).

Isoform 6:
May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.

Cell differentiation Source: UniProtKB-KW
Fatty acid metabolic process Source: Ensembl
Glucose metabolic process Source: Ensembl
Multicellular organism development Source: UniProtKB-KW
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of circadian rhythm Source: Ensembl
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Retinoic acid receptor signaling pathway Source: Ensembl
Rhythmic process Source: UniProtKB-KW
Signal transduction Source: ProtInc
Spermatogenesis Source: UniProtKB-KW

Nucleus
Isoform 6: Cytoplasm; Nucleus

Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.
Stimulated by phosphorylation. Phosphorylated on Ser-116 by TSSK4 in vitro.