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Mouse Anti-CREM Recombinant Antibody (3B5) (CBMAB-C5731-LY)

This product is antibody recognizes CREM . The antibody 3B5 immunoassay techniques such as: ELISA, IF, WB.
See all CREM antibodies
Published Data
Fig.1 Increased Crem protein expression in the nuclei of HCC tumor cells.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B5
Antibody Isotype
IgG1, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa201-300 from human CREM (NP_853549) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CAMP Responsive Element Modulator
Entrez Gene ID
1390
UniProt ID
Q03060
Alternative Names
CAMP Responsive Element Modulator; ICER; Inducible CAMP Early Repressor ICER; CAMP-Responsive Element Modulator; CAMP Response Element Modulator; Inducible CAMP Early Repressor;
Function
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).

Isoform 6:
May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.
Biological Process
Cell differentiation Source: UniProtKB-KW
Fatty acid metabolic process Source: Ensembl
Glucose metabolic process Source: Ensembl
Multicellular organism development Source: UniProtKB-KW
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of circadian rhythm Source: Ensembl
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Retinoic acid receptor signaling pathway Source: Ensembl
Rhythmic process Source: UniProtKB-KW
Signal transduction Source: ProtInc
Spermatogenesis Source: UniProtKB-KW
Cellular Location
Nucleus
Isoform 6: Cytoplasm; Nucleus
PTM
Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.
Stimulated by phosphorylation. Phosphorylated on Ser-116 by TSSK4 in vitro.

Jeon, Y. J., Yi, S. A., Lee, J., & Han, J. W. (2022). Nuclear S6K1 regulates cAMP-responsive element-dependent gene transcription through activation of mTOR signal pathway. Biochemical and Biophysical Research Communications.

Subramanyam, S. H., & Tenbrock, K. (2021). The cAMP responsive element modulator (CREM) is a regulator of CD4+ T cell function. Biological Chemistry, 402(12), 1591-1596.

Jazireian, P., Favaedi, R., Gilani, M. A. S., & Shahhoseini, M. (2021). Dynamic Expression and Chromatin Incorporation of ACT and CREM Transcription Factors in Testis Tissues of Infertile Men. Cell Journal (Yakhteh), 23(7), 736.

Hofmann, S. R., Mäbert, K., Kapplusch, F., Russ, S., Northey, S., Beresford, M. W., ... & Hedrich, C. M. (2019). cAMP response element modulator α induces dual specificity protein phosphatase 4 to promote effector T cells in juvenile-onset lupus. The Journal of Immunology, 203(11), 2807-2816.

Zhou, Y., Ji, J., Zhuang, J., Wang, L., & Hong, F. (2019). Nanoparticulate TiO2 induced suppression of spermatogenesis is involved in regulatory dysfunction of the cAMP-CREB/CREM signaling pathway in mice. Journal of Biomedical Nanotechnology, 15(3), 571-580.

Yogi, A. B. A. W. C., de Fatima, Y. L. A., & Machado, W. F. U. F. (2019). Sympathetic regulation of Slc2a4 gene expression: participation of a putative cAMP responsive element (CRE) site in the Slc2a4 promoter. Cell Physiol Biochem, 52, 580-594.

Kuttkat, N., Mohs, A., Ohl, K., Hooiveld, G., Longerich, T., Tenbrock, K., ... & Trautwein, C. (2017). Hepatic overexpression of cAMP-responsive element modulator α induces a regulatory T-cell response in a murine model of chronic liver disease. Gut, 66(5), 908-919.

Zhang, J., Zhu, Y., Liang, C., Qie, M., Niu, R., Sun, Z., ... & Wang, J. (2017). Effects of fluoride on expression of P450, CREM and ACT proteins in rat testes. Biological trace element research, 175(1), 156-160.

Marchese, E., Di Maria, V., Samengo, D., Pani, G., Michetti, F., & Geloso, M. C. (2017). Post-natal deletion of neuronal cAMP responsive-element binding (CREB)-1 promotes pro-inflammatory changes in the mouse hippocampus. Neurochemical Research, 42(8), 2230-2245.

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For research use only. Not intended for any clinical use.

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