CRHR2

CRHR2 (Corticotropin Releasing Hormone Receptor 2) is a Protein Coding gene. Diseases associated with CRHR2 include Anxiety and Panic Disorder. Among its related pathways are Peptide hormone metabolism and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and hormone activity. An important paralog of this gene is CRHR1.

Full Name

Corticotropin Releasing Hormone Receptor 2

Function

G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.

Biological Process

Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
Cell surface receptor signaling pathway Source: InterPro
G protein-coupled receptor signaling pathway Source: Reactome
Long-term synaptic potentiation Source: GO_Central
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome

Cellular Location

Cell membrane

Topology

Extracellular: 1-108
Helical: 109-139
Cytoplasmic: 140-146
Helical: 147-171
Extracellular: 172-185
Helical: 186-214
Cytoplasmic: 215-221
Helical: 222-249
Extracellular: 250-265
Helical: 266-291
Cytoplasmic: 292-302
Helical: 303-327
Extracellular: 328-334
Helical: 335-364
Cytoplasmic: 365-411

PTM

A N-glycosylation site within the signal peptide impedes its proper cleavage and function.

Anti-CRHR2 antibodies

Rabbit Anti-CRHR2 Recombinant Antibody (EG828) (CBMAB-EN986-LY)

Datasheet

SDS

Target: CRHR2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG828

Application*: WB: 1:500~1:1000 ELISA: 1:10000

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)