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Rabbit Anti-CRHR2 Recombinant Antibody (EG828) (CBMAB-EN986-LY)

The product is antibody recognizes CRFR2. The antibody EG828 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:10000.
See all CRHR2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG828
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human CRFR2.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Corticotropin Releasing Hormone Receptor 2
Introduction
CRHR2 (Corticotropin Releasing Hormone Receptor 2) is a Protein Coding gene. Diseases associated with CRHR2 include Anxiety and Panic Disorder. Among its related pathways are Peptide hormone metabolism and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and hormone activity. An important paralog of this gene is CRHR1.
Entrez Gene ID
Human1395
Mouse12922
Rat64680
UniProt ID
HumanQ13324
MouseQ60748
RatP47866
Alternative Names
Corticotropin Releasing Hormone Receptor 2; CRH-R2; Corticotropin-Releasing Hormone Receptor 2; Corticotropin-Releasing Factor Receptor 2; CRF2 Receptor, Beta Isoform; CRH Receptor 2 Variant B; CRF-R-2; CRH-R-2; CRF-RB;
Function
G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
Biological Process
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
Cell surface receptor signaling pathway Source: InterPro
G protein-coupled receptor signaling pathway Source: Reactome
Long-term synaptic potentiation Source: GO_Central
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Cellular Location
Cell membrane
Topology
Extracellular: 1-108
Helical: 109-139
Cytoplasmic: 140-146
Helical: 147-171
Extracellular: 172-185
Helical: 186-214
Cytoplasmic: 215-221
Helical: 222-249
Extracellular: 250-265
Helical: 266-291
Cytoplasmic: 292-302
Helical: 303-327
Extracellular: 328-334
Helical: 335-364
Cytoplasmic: 365-411
PTM
A N-glycosylation site within the signal peptide impedes its proper cleavage and function.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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