CRIM1

Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed Sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) and transforming growth factor-beta (e.g., TGFB1; MIM 190180) families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival (Kolle et al., 2000 [PubMed 10642437]).[supplied by OMIM

cysteine rich transmembrane BMP regulator 1 (chordin-like)

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.

Negative regulation of BMP signaling pathway Source: ARUK-UCL
Negative regulation of osteoblast differentiation Source: ARUK-UCL
Nervous system development Source: ProtInc

Processed cysteine-rich motor neuron 1 protein: Secreted; Cell membrane

Extracellular: 35-939
Helical: 940-960
Cytoplasmic: 961-1036

N-glycosylated.