CRMP1

This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

collapsin response mediator protein 1

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863).

Plays a role in axon guidance (PubMed:25358863).

During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863).

Involved in invasive growth and cell migration (PubMed:11562390).

May participate in cytokinesis (PubMed:19799413).

Axon guidance Source: InterPro
Microtubule cytoskeleton organization Source: InterPro
Negative regulation of actin filament binding Source: WormBase
Negative regulation of neuron projection development Source: WormBase
Nervous system development Source: ProtInc
Nucleobase-containing compound metabolic process Source: ProtInc

Centrosome; Spindle; Cytoskeleton; Cytoplasm; Growth cone; Perikaryon. Associated with centrosomes and the mitotic spindle during metaphase (PubMed:11562390). Colocalizes with FLNA and tubulin in the central region of DRG neuron growth cone (By similarity). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity).

Phosphorylation at Ser-522 enhances CRMP1-mediated alteration of FLNA ternary structure and FLNA dissociation from F-actin.