CSTA1

This is an intracellular thiol proteinase inhibitor. Low expression observed in reference dataset.

CYSTATIN A1

This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.

Cell-cell adhesion Source: UniProtKB
Cornification Source: Reactome
Keratinocyte differentiation Source: UniProtKB
Negative regulation of peptidase activity Source: BHF-UCL
Negative regulation of proteolysis Source: UniProtKB
Peptide cross-linking Source: UniProtKB

Cytoplasm

Peeling skin syndrome 4 (PSS4):
A genodermatosis characterized by congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. PSS4 presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.