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Rat Anti-CSTA1 (AA 2-97) Recombinant Antibody (CBFYC-2356) (CBMAB-C2428-FY)

This product is rat antibody that recognizes CSTA1. The antibody CBFYC-2356 can be used for immunoassay techniques such as: WB, IP.
See all CSTA1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYC-2356
Antibody Isotype
IgG2a
Application
WB, IP

Basic Information

Immunogen
Recombinant mouse Cystatin/Stefin Homolog, Ile2-Phe97
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 2-97

Target

Full Name
CYSTATIN A1
Introduction
This is an intracellular thiol proteinase inhibitor. Low expression observed in reference dataset.
Entrez Gene ID
209294
UniProt ID
P56567
Alternative Names
Csta
Function
This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.
Biological Process
Cell-cell adhesion Source: UniProtKB
Cornification Source: Reactome
Keratinocyte differentiation Source: UniProtKB
Negative regulation of peptidase activity Source: BHF-UCL
Negative regulation of proteolysis Source: UniProtKB
Peptide cross-linking Source: UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Peeling skin syndrome 4 (PSS4):
A genodermatosis characterized by congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens and annular epidermolytic ichthyosis. PSS4 presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms and soles, which is exacerbated by excessive moisture and minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal and suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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