CUL4B

CUL4B (Cullin 4B) is a Protein Coding gene. Diseases associated with CUL4B include Mental Retardation, X-Linked, Syndromic, Cabezas Type and Seizure Disorder. Among its related pathways are Mesodermal Commitment Pathway and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and damaged DNA binding. An important paralog of this gene is CUL4A.

Cullin 4B

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8. With CUL4A, contributes to ribosome biogenesis (PubMed:26711351).

Cellular response to DNA damage stimulus Source: GO_Central
DNA damage response, detection of DNA damage Source: Reactome
G1/S transition of mitotic cell cycle Source: UniProtKB
Global genome nucleotide-excision repair Source: Reactome
Histone H2A monoubiquitination Source: UniProtKB
Nucleotide-excision repair, DNA damage recognition Source: Reactome
Nucleotide-excision repair, DNA duplex unwinding Source: Reactome
Nucleotide-excision repair, DNA incision Source: Reactome
Nucleotide-excision repair, DNA incision, 3'-to lesion Source: Reactome
Nucleotide-excision repair, DNA incision, 5'-to lesion Source: Reactome
Nucleotide-excision repair, preincision complex assembly Source: Reactome
Nucleotide-excision repair, preincision complex stabilization Source: Reactome
Post-translational protein modification Source: Reactome
Proteasomal protein catabolic process Source: MGI
Protein ubiquitination Source: UniProtKB
Ribosome biogenesis Source: UniProtKB
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
Transcription-coupled nucleotide-excision repair Source: Reactome
UV-damage excision repair Source: UniProtKB

Nucleus

Mental retardation, X-linked, syndromic, 15 (MRXS15):
A syndromic form of X-linked mental retardation characterized by severe intellectual deficit associated with short stature, craniofacial dysmorphism, small testes, muscle wasting in lower legs, kyphosis, joint hyperextensibility, pes cavus, small feet, and abnormalities of the toes. Additional neurologic manifestations include speech delay and impairment, tremor, seizures, gait ataxia, hyperactivity and decreased attention span.

Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.