CYB5R4

NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 250790) and CYB5 reductase (see MIM 250800).[supplied by OMIM

Full Name

cytochrome b5 reductase 4

Function

NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.

Biological Process

Bicarbonate transport Source: Reactome
Cell development Source: UniProtKB
Detection of oxygen Source: UniProtKB
Generation of precursor metabolites and energy Source: UniProtKB
Glucose homeostasis Source: UniProtKB
Insulin secretion Source: UniProtKB
Reactive oxygen species metabolic process Source: UniProtKB
Response to antibiotic Source: UniProtKB
Superoxide metabolic process Source: UniProtKB

Cellular Location

Endoplasmic reticulum. Soluble protein.

Anti-CYB5R4 antibodies

Mouse Anti-CYB5R4 (AA 388-487) Recombinant Antibody (CBFYC-2555) (CBMAB-C2629-FY)

Datasheet

SDS

Target: CYB5R4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYC-2555

Application*: E, WB

Mouse Anti-CYB5R4 Recombinant Antibody (4B8) (CBMAB-C6689-LY)

Datasheet

SDS

Target: CYB5R4

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human

Clone: 4B8

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)