CYP3A5

CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) is a Protein Coding gene. Diseases associated with CYP3A5 include Hypertension, Essential and Tacrolimus Dose Selection. Among its related pathways are Tamoxifen Pathway, Pharmacokinetics and Vinka Alkaloid Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and heme binding. An important paralog of this gene is CYP3A4.

Cytochrome P450 Family 3 Subfamily A Member 5

A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:2732228, PubMed:10681376, PubMed:11093772, PubMed:12865317).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:2732228, PubMed:10681376, PubMed:11093772).

Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317).

Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed:2732228).

Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376).

Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772).

Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed:2732228).

Aflatoxin metabolic process Source: Reactome
Alkaloid catabolic process Source: BHF-UCL
Drug catabolic process Source: BHF-UCL
Estrogen metabolic process Source: UniProtKB
Lipid hydroxylation Source: BHF-UCL
Oxidative demethylation Source: BHF-UCL
Retinoic acid metabolic process Source: UniProtKB
Retinol metabolic process Source: UniProtKB-UniPathway
Steroid metabolic process Source: BHF-UCL
Xenobiotic metabolic process Source: Reactome

Endoplasmic reticulum membrane; Microsome membrane