CYSLTR1

CYSLTR1 (Cysteinyl Leukotriene Receptor 1) is a Protein Coding gene. Diseases associated with CYSLTR1 include Asthma and Adenoid Hypertrophy. Among its related pathways are Endothelins and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and leukotriene receptor activity. An important paralog of this gene is CYSLTR2.

Cysteinyl Leukotriene Receptor 1

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4>> LTE4 = LTC4>> LTB4.

Calcium ion transport Source: Ensembl
Cell surface receptor signaling pathway Source: Ensembl
Chemotaxis Source: Ensembl
Defense response Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response to antigenic stimulus Source: Ensembl
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Neuropeptide signaling pathway Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: ProtInc
Respiratory gaseous exchange by respiratory system Source: ProtInc

Cell membrane

Extracellular: 1-28
Helical: 29-49
Cytoplasmic: 50-57
Helical: 58-78
Extracellular: 79-106
Helical: 107-127
Cytoplasmic: 128-141
Helical: 142-162
Extracellular: 163-193
Helical: 194-214
Cytoplasmic: 215-230
Helical: 231-251
Extracellular: 252-276
Helical: 277-297
Cytoplasmic: 298-337