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Rabbit Anti-CYSLTR1 Recombinant Antibody (EG738) (CBMAB-EN893-LY)

The product is antibody recognizes CLTR1. The antibody EG738 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:10000.
See all CYSLTR1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG738
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human CLTR1.
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cysteinyl Leukotriene Receptor 1
Introduction
CYSLTR1 (Cysteinyl Leukotriene Receptor 1) is a Protein Coding gene. Diseases associated with CYSLTR1 include Asthma and Adenoid Hypertrophy. Among its related pathways are Endothelins and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and leukotriene receptor activity. An important paralog of this gene is CYSLTR2.
Entrez Gene ID
10800
UniProt ID
Q9Y271
Alternative Names
Cysteinyl Leukotriene Receptor 1; Cysteinyl Leukotriene D4 Receptor; G-Protein Coupled Receptor HG55; LTD4 Receptor; HMTMF81; CYSLT1; CYSLT1R; CysLTR1; CYSLTR;
Function
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4>> LTE4 = LTC4>> LTB4.
Biological Process
Calcium ion transport Source: Ensembl
Cell surface receptor signaling pathway Source: Ensembl
Chemotaxis Source: Ensembl
Defense response Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response to antigenic stimulus Source: Ensembl
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Neuropeptide signaling pathway Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: ProtInc
Respiratory gaseous exchange by respiratory system Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-28
Helical: 29-49
Cytoplasmic: 50-57
Helical: 58-78
Extracellular: 79-106
Helical: 107-127
Cytoplasmic: 128-141
Helical: 142-162
Extracellular: 163-193
Helical: 194-214
Cytoplasmic: 215-230
Helical: 231-251
Extracellular: 252-276
Helical: 277-297
Cytoplasmic: 298-337

Li, Z., Wang, J., & Ma, Y. (2021). Montelukast attenuates interleukin IL-1β-induced oxidative stress and apoptosis in chondrocytes by inhibiting CYSLTR1 (Cysteinyl Leukotriene Receptor 1) and activating KLF2 (Kruppel Like Factor 2). Bioengineered, 12(1), 8476-8484.

Satapathy, S. R., & Sjölander, A. (2020). Cysteinyl leukotriene receptor 1 promotes 5-fluorouracil resistance and resistance-derived stemness in colon cancer cells. Cancer letters, 488, 50-62.

Ruiz, I., Nevers, Q., Hernández, E., Ahnou, N., Brillet, R., Softic, L., ... & Ahmed-Belkacem, A. (2020). MK-571, a cysteinyl leukotriene receptor 1 antagonist, inhibits hepatitis C virus replication. Antimicrobial Agents and Chemotherapy, 64(6), e02078-19.

Koller, A., Bruckner, D., Aigner, L., Reitsamer, H., & Trost, A. (2020). Cysteinyl leukotriene receptor 1 modulates autophagic activity in retinal pigment epithelial cells. Scientific reports, 10(1), 1-13.

Slater, K., Heeran, A. B., Garcia-Mulero, S., Kalirai, H., Sanz-Pamplona, R., Rahman, A., ... & Kennedy, B. N. (2020). High cysteinyl leukotriene receptor 1 expression correlates with poor survival of uveal melanoma patients and cognate antagonist drugs modulate the growth, cancer secretome, and metabolism of uveal melanoma cells. Cancers, 12(10), 2950.

Wang, Y., Yang, Y., Zhang, S., Li, C., & Zhang, L. (2020). Modulation of neuroinflammation by cysteinyl leukotriene 1 and 2 receptors: Implications for cerebral ischemia and neurodegenerative diseases. Neurobiology of Aging, 87, 1-10.

Trinh, H. K. T., Suh, D. H., Nguyen, T. V. T., Choi, Y., Park, H. S., & Shin, Y. S. (2019). Characterization of cysteinyl leukotriene-related receptors and their interactions in a mouse model of asthma. Prostaglandins, Leukotrienes and Essential Fatty Acids, 141, 17-23.

Song, W., Zhang, Y., Wang, J., Ma, T., Hao, L., & Wang, K. (2018). Antagonism of cysteinyl leukotriene receptor 1 (cysLTR1) by montelukast suppresses cell senescence of chondrocytes. Cytokine, 103, 83-89.

Dolinska, M., Piccini, A., Wong, W. M., Gelali, E., Johansson, A. S., Klang, J., ... & Qian, H. (2017). Leukotriene signaling via ALOX5 and cysteinyl leukotriene receptor 1 is dispensable for in vitro growth of CD34+ CD38− stem and progenitor cells in chronic myeloid leukemia. Biochemical and biophysical research communications, 490(2), 378-384.

Osman, J., Savari, S., Chandrashekar, N. K., Bellamkonda, K., Douglas, D., & Sjölander, A. (2017). Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer. Oncotarget, 8(21), 34773.

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For research use only. Not intended for any clinical use.

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