DNAL4

This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella.

Full Name

dynein axonemal light chain 4

Function

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity).

Biological Process

Microtubule-based movement Source: Reactome
Positive regulation of ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central

Cellular Location

Cilium axoneme

Involvement in disease

Mirror movements 3 (MRMV3):
A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.

Anti-DNAL4 antibodies

Mouse Anti-DNAL4 Recombinant Antibody (4D12-C10-D5) (CBMAB-Z0298-LY)

Datasheet

SDS

Target: DNAL4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4D12-C10-D5

Application*: WB, F

Mouse Anti-DNAL4 Recombinant Antibody (14i134) (CBMAB-D1330-YC)

Datasheet

SDS

Target: DNAL4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 14i134

Application*: E, F, WB

Mouse Anti-DNAL4 Recombinant Antibody (14i136) (CBMAB-D1332-YC)

Datasheet

SDS

Target: DNAL4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 14i136

Application*: E, IH, WB

Mouse Anti-DNAL4 Recombinant Antibody (3B7B7) (CBMAB-D1333-YC)

Datasheet

SDS

Target: DNAL4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3B7B7

Application*: E, WB, P, IC, IF, F

Mouse Anti-DNAL4 Recombinant Antibody (3C10A4) (CBMAB-D1334-YC)

Datasheet

SDS

Target: DNAL4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3C10A4

Application*: E, IH, P, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)