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DPP10

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Full Name

Dipeptidyl Peptidase Like 10

Function

Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437).

Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437).

Has no dipeptidyl aminopeptidase activity (PubMed:12662155).

Biological Process

Positive regulation of protein localization to plasma membrane Source: CACAO
Protein localization to plasma membrane Source: UniProtKB
Regulation of potassium ion transmembrane transport Source: UniProtKB

Cellular Location

Cell membrane

Involvement in disease

Asthma (ASTHMA):
The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.

Topology

Cytoplasmic: 1-34
Helical: 35-55
Extracellular: 56-796

PTM

N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.

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Anti-DPP10 antibodies

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Rat Anti-DPP10 Recombinant Antibody (453601) (CBMAB-D1565-YC)

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Target: DPP10

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human

Clone: 453601

Application*: WB

Rabbit Anti-DPP10 Recombinant Antibody (4) (CBMAB-D1564-YC)

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Target: DPP10

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 4

Application*: E, WB

Mouse Anti-DPP10 Recombinant Antibody (1A5) (CBMAB-D1562-YC)

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Target: DPP10

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1A5

Application*: F, P, WB

Mouse Anti-DPP10 Recombinant Antibody (D1565) (V2LY-0425-LY832)

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Target: DPP10

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: D1565

Application*: WB, IP, IF, E

Rabbit Anti-DPP10 Recombinant Antibody (4) (V2LY-0425-LY831)

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Target: DPP10

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 4

Application*: E

Mouse Anti-DPP10 Recombinant Antibody (D1562) (V2LY-0425-LY830)

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Target: DPP10

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: D1562

Application*: WB, IP, IF, E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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