DPP10

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Full Name
Dipeptidyl Peptidase Like 10
Function
Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437).

Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437).

Has no dipeptidyl aminopeptidase activity (PubMed:12662155).
Biological Process
Positive regulation of protein localization to plasma membrane Source: CACAO
Protein localization to plasma membrane Source: UniProtKB
Regulation of potassium ion transmembrane transport Source: UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Asthma (ASTHMA):
The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
Topology
Cytoplasmic: 1-34
Helical: 35-55
Extracellular: 56-796
PTM
N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.
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Anti-DPP10 antibodies

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Rat Anti-DPP10 Recombinant Antibody (453601) (CBMAB-D1565-YC)

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Target: DPP10
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 453601
Application*: WB
Datasheet SDS

Rabbit Anti-DPP10 Recombinant Antibody (4) (CBMAB-D1564-YC)

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Target: DPP10
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 4
Application*: E, WB
Datasheet SDS

Mouse Anti-DPP10 Recombinant Antibody (1A5) (CBMAB-D1562-YC)

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Target: DPP10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A5
Application*: F, P, WB
Datasheet SDS

Mouse Anti-DPP10 Recombinant Antibody (D1565) (V2LY-0425-LY832)

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Target: DPP10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: D1565
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-DPP10 Recombinant Antibody (4) (V2LY-0425-LY831)

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Target: DPP10
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 4
Application*: E
Datasheet SDS

Mouse Anti-DPP10 Recombinant Antibody (D1562) (V2LY-0425-LY830)

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Target: DPP10
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: D1562
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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