Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-DPP10 Recombinant Antibody (D1565) (V2LY-0425-LY832)


See all DPP10 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
D1565
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 155-182 within an internal region of mouse DPP10.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dipeptidyl Peptidase Like 10
Entrez Gene ID
57628
UniProt ID
Q8N608
Function
Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437).

Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437).

Has no dipeptidyl aminopeptidase activity (PubMed:12662155).
Biological Process
Positive regulation of protein localization to plasma membrane Source: CACAO
Protein localization to plasma membrane Source: UniProtKB
Regulation of potassium ion transmembrane transport Source: UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Asthma (ASTHMA):
The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
Topology
Cytoplasmic: 1-34
Helical: 35-55
Extracellular: 56-796
PTM
N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.
More Infomation

Sim, S., Choi, Y., Lee, D. H., Lee, H. R., Seob Shin, Y., & Park, H. S. (2022). Contribution of dipeptidyl peptidase 10 to airway dysfunction in patients with NSAID‐exacerbated respiratory disease. Clinical & Experimental Allergy, 52(1), 115-126.

Qian, X. K., Zhang, J., Li, X. D., Song, P. F., & Zou, L. W. (2022). Research Progress on Dipeptidyl Peptidase Family: Structure, Function and Xenobiotic Metabolism. Current Medicinal Chemistry.

Choy, T. K., Wang, C. Y., Phan, N. N., Khoa Ta, H. D., Anuraga, G., Liu, Y. H., ... & Kao, T. J. (2021). Identification of Dipeptidyl Peptidase (DPP) family genes in clinical breast cancer patients via an integrated bioinformatics approach. Diagnostics, 11(7), 1204.

Metzner, K. (2020). The impact of the β-subunit DPP10 on cardiac action potential and native voltage-gated K+ and Na+ currents.

Belau, F., Metzner, K., Christ, T., Ravens, U., Schaefer, M., Künzel, S., ... & Kämmerer, S. (2019). DPP10 is a new regulator of Nav1. 5 channels in human heart. International Journal of Cardiology, 284, 68-73.

Ni, H., Rajamani, S., & Giles, W. R. (2019). Novel regulation of the mammalian cardiac Na+ channel by dipeptidyl peptidase 10 interactions: An editorial comment. International journal of cardiology, 284, 74-76.

Zhang, Y., Poobalasingam, T., Yates, L. L., Walker, S. A., Taylor, M. S., Chessum, L., ... & Dean, C. H. (2018). Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma. Disease models & mechanisms, 11(1), dmm031369.

Sato, A., & Ogita, H. (2017). Pathophysiological implications of dipeptidyl peptidases. Current Protein and Peptide Science, 18(8), 843-849.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-DPP10 Recombinant Antibody (D1565)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry