Mouse Anti-DPP10 Recombinant Antibody (D1565) (V2LY-0425-LY832)

Name: Mouse Anti-DPP10 Recombinant Antibody (D1565)
SKU: V2LY-0425-LY832
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

D1565

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 155-182 within an internal region of mouse DPP10.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Dipeptidyl Peptidase Like 10

Entrez Gene ID

57628

UniProt ID

Q8N608

Function

Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437).

Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437).

Has no dipeptidyl aminopeptidase activity (PubMed:12662155).

Biological Process

Positive regulation of protein localization to plasma membrane Source: CACAO
Protein localization to plasma membrane Source: UniProtKB
Regulation of potassium ion transmembrane transport Source: UniProtKB

Cellular Location

Cell membrane

Involvement in disease

Asthma (ASTHMA):
The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.

Topology

Cytoplasmic: 1-34
Helical: 35-55
Extracellular: 56-796

PTM

N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.

Sim, S., Choi, Y., Lee, D. H., Lee, H. R., Seob Shin, Y., & Park, H. S. (2022). Contribution of dipeptidyl peptidase 10 to airway dysfunction in patients with NSAID‐exacerbated respiratory disease. Clinical & Experimental Allergy, 52(1), 115-126.

Qian, X. K., Zhang, J., Li, X. D., Song, P. F., & Zou, L. W. (2022). Research Progress on Dipeptidyl Peptidase Family: Structure, Function and Xenobiotic Metabolism. Current Medicinal Chemistry.

Choy, T. K., Wang, C. Y., Phan, N. N., Khoa Ta, H. D., Anuraga, G., Liu, Y. H., ... & Kao, T. J. (2021). Identification of Dipeptidyl Peptidase (DPP) family genes in clinical breast cancer patients via an integrated bioinformatics approach. Diagnostics, 11(7), 1204.

Metzner, K. (2020). The impact of the β-subunit DPP10 on cardiac action potential and native voltage-gated K+ and Na+ currents.

Belau, F., Metzner, K., Christ, T., Ravens, U., Schaefer, M., Künzel, S., ... & Kämmerer, S. (2019). DPP10 is a new regulator of Nav1. 5 channels in human heart. International Journal of Cardiology, 284, 68-73.

Ni, H., Rajamani, S., & Giles, W. R. (2019). Novel regulation of the mammalian cardiac Na+ channel by dipeptidyl peptidase 10 interactions: An editorial comment. International journal of cardiology, 284, 74-76.

Zhang, Y., Poobalasingam, T., Yates, L. L., Walker, S. A., Taylor, M. S., Chessum, L., ... & Dean, C. H. (2018). Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma. Disease models & mechanisms, 11(1), dmm031369.

Sato, A., & Ogita, H. (2017). Pathophysiological implications of dipeptidyl peptidases. Current Protein and Peptide Science, 18(8), 843-849.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rabbit Anti-DPP10 Recombinant Antibody (4) (CAT#: V2LY-0425-LY831)

Mouse Anti-DPP10 Recombinant Antibody (1A5) (CAT#: CBMAB-D1562-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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