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Mouse Anti-DPP10 Recombinant Antibody (1A5) (CBMAB-D1562-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dipeptidyl Peptidase Like 10 (DPP10). The antibody can be used for immunoassay techniques, such as FC, IHC-P, WB.
See all DPP10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A5
Antibody Isotype
IgG1
Application
FC, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dipeptidyl Peptidase Like 10
Introduction
DPP10 is a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Entrez Gene ID
57628
UniProt ID
Q8N608
Alternative Names
Dipeptidyl Peptidase Like 10; Dipeptidyl Peptidase IV-Related Protein 3; Dipeptidyl Peptidase-Like Protein 2; Dipeptidyl-Peptidase 10 (Inactive); Dipeptidyl Peptidase X; DPRP-3; DPP X; DPRP3; DPL2;
Function
Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437).

Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437).

Has no dipeptidyl aminopeptidase activity (PubMed:12662155).
Biological Process
Positive regulation of protein localization to plasma membrane Source: CACAO
Protein localization to plasma membrane Source: UniProtKB
Regulation of potassium ion transmembrane transport Source: UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Asthma (ASTHMA):
The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
Topology
Cytoplasmic: 1-34
Helical: 35-55
Extracellular: 56-796
PTM
N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.

Sim, S., Choi, Y., Lee, D. H., Lee, H. R., Seob Shin, Y., & Park, H. S. (2022). Contribution of dipeptidyl peptidase 10 to airway dysfunction in patients with NSAID‐exacerbated respiratory disease. Clinical & Experimental Allergy, 52(1), 115-126.

Qian, X. K., Zhang, J., Li, X. D., Song, P. F., & Zou, L. W. (2022). Research Progress on Dipeptidyl Peptidase Family: Structure, Function and Xenobiotic Metabolism. Current Medicinal Chemistry.

Choy, T. K., Wang, C. Y., Phan, N. N., Khoa Ta, H. D., Anuraga, G., Liu, Y. H., ... & Kao, T. J. (2021). Identification of Dipeptidyl Peptidase (DPP) family genes in clinical breast cancer patients via an integrated bioinformatics approach. Diagnostics, 11(7), 1204.

Metzner, K. (2020). The impact of the β-subunit DPP10 on cardiac action potential and native voltage-gated K+ and Na+ currents.

Belau, F., Metzner, K., Christ, T., Ravens, U., Schaefer, M., Künzel, S., ... & Kämmerer, S. (2019). DPP10 is a new regulator of Nav1. 5 channels in human heart. International Journal of Cardiology, 284, 68-73.

Ni, H., Rajamani, S., & Giles, W. R. (2019). Novel regulation of the mammalian cardiac Na+ channel by dipeptidyl peptidase 10 interactions: An editorial comment. International journal of cardiology, 284, 74-76.

Zhang, Y., Poobalasingam, T., Yates, L. L., Walker, S. A., Taylor, M. S., Chessum, L., ... & Dean, C. H. (2018). Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma. Disease models & mechanisms, 11(1), dmm031369.

Sato, A., & Ogita, H. (2017). Pathophysiological implications of dipeptidyl peptidases. Current Protein and Peptide Science, 18(8), 843-849.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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