Human Recombinant DPP10 protein, His Tag (V2LY-0526-LY3628)

Name: Human Recombinant DPP10 protein, His Tag
SKU: V2LY-0526-LY3628
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant DPP10 protein, His Tag consist of Amino Acid: 56-796 and predicts a molecular mass of 87.4 kDa.

Molecule Mass

87.4 kDa

Sequence

Amino Acid: 56-796

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>97% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Dipeptidyl Peptidase Like 10

Function

Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437).

Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437).

Has no dipeptidyl aminopeptidase activity (PubMed:12662155).

Biological Process

Positive regulation of protein localization to plasma membrane Source: CACAO
Protein localization to plasma membrane Source: UniProtKB
Regulation of potassium ion transmembrane transport Source: UniProtKB

Cellular Location

Cell membrane

Involvement in disease

Asthma (ASTHMA):
The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.

Topology

Cytoplasmic: 1-34
Helical: 35-55
Extracellular: 56-796

PTM

N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.

Sim, S., Choi, Y., Lee, D. H., Lee, H. R., Seob Shin, Y., & Park, H. S. (2022). Contribution of dipeptidyl peptidase 10 to airway dysfunction in patients with NSAID‐exacerbated respiratory disease. Clinical & Experimental Allergy, 52(1), 115-126.

Qian, X. K., Zhang, J., Li, X. D., Song, P. F., & Zou, L. W. (2022). Research Progress on Dipeptidyl Peptidase Family: Structure, Function and Xenobiotic Metabolism. Current Medicinal Chemistry.

Choy, T. K., Wang, C. Y., Phan, N. N., Khoa Ta, H. D., Anuraga, G., Liu, Y. H., ... & Kao, T. J. (2021). Identification of Dipeptidyl Peptidase (DPP) family genes in clinical breast cancer patients via an integrated bioinformatics approach. Diagnostics, 11(7), 1204.

Metzner, K. (2020). The impact of the β-subunit DPP10 on cardiac action potential and native voltage-gated K+ and Na+ currents.

Belau, F., Metzner, K., Christ, T., Ravens, U., Schaefer, M., Künzel, S., ... & Kämmerer, S. (2019). DPP10 is a new regulator of Nav1. 5 channels in human heart. International Journal of Cardiology, 284, 68-73.

Ni, H., Rajamani, S., & Giles, W. R. (2019). Novel regulation of the mammalian cardiac Na+ channel by dipeptidyl peptidase 10 interactions: An editorial comment. International journal of cardiology, 284, 74-76.

Zhang, Y., Poobalasingam, T., Yates, L. L., Walker, S. A., Taylor, M. S., Chessum, L., ... & Dean, C. H. (2018). Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma. Disease models & mechanisms, 11(1), dmm031369.

Sato, A., & Ogita, H. (2017). Pathophysiological implications of dipeptidyl peptidases. Current Protein and Peptide Science, 18(8), 843-849.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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