DYNC1LI1

The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking.

DYNEIN CYTOPLASMIC 1 LIGHT INTERMEDIATE CHAIN 1

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.

Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Microtubule-based movement Source: GO_Central
Microtubule cytoskeleton organization Source: GO_Central
Positive regulation of mitotic cell cycle spindle assembly checkpoint Source: UniProtKB

Cytoplasm; Spindle pole; Kinetochore

Phosphorylated during mitosis but not in interphase.