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Mouse Anti-DYNC1LI1 Recombinant Antibody (1B9) (CBMAB-D1993-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1B9
Antibody Isotype
IgG2b
Application
FC, IF, WB

Basic Information

Immunogen
Full length human recombinant protein of human DYNC1LI1 (NP_057225) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DYNEIN CYTOPLASMIC 1 LIGHT INTERMEDIATE CHAIN 1
Introduction
DYNC1LI1 belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking.
Entrez Gene ID
51143
UniProt ID
Q9Y6G9
Alternative Names
Dynein Cytoplasmic 1 Light Intermediate Chain 1; Dynein, Cytoplasmic, Light Intermediate Polypeptide 1; Dynein Light Intermediate Chain 1, Cytosolic; Dynein Light Chain A; DNCLI1; DLC-A; LIC1; Cytoplasmic Dynein 1 Light Intermediate Chain 1;
Research Area
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.
Biological Process
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Microtubule-based movement Source: GO_Central
Microtubule cytoskeleton organization Source: GO_Central
Positive regulation of mitotic cell cycle spindle assembly checkpoint Source: UniProtKB
Cellular Location
Cytoplasm; Spindle pole; Kinetochore
PTM
Phosphorylated during mitosis but not in interphase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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