DYNLT3

DYNLT3 belongs to a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator.

Dynein Light Chain Tctex-Type 3

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).

Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Positive regulation of mitotic cell cycle Source: Ensembl
Regulation of mitotic cell cycle Source: UniProtKB

Nucleus; Cytoskeleton; Kinetochore. Colocalizes with BUB3 at kinetochores specifically during prometaphase.