E2F1

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

E2F Transcription Factor 1

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812).

Positively regulates transcription of RRP1B (PubMed:20040599).

Anoikis Source: Ensembl
Cellular response to fatty acid Source: Ensembl
Cellular response to hypoxia Source: Ensembl
Cellular response to nerve growth factor stimulus Source: Ensembl
Cellular response to xenobiotic stimulus Source: Ensembl
DNA damage checkpoint signaling Source: UniProtKB
Forebrain development Source: Ensembl
G1/S transition of mitotic cell cycle Source: GO_Central
Intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
Intrinsic apoptotic signaling pathway in response to DNA damage Source: UniProtKB
Lens fiber cell apoptotic process Source: Ensembl
mRNA stabilization Source: BHF-UCL
Negative regulation of DNA binding Source: UniProtKB
Negative regulation of fat cell differentiation Source: UniProtKB
Negative regulation of fat cell proliferation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Negative regulation of transcription involved in G1/S transition of mitotic cell cycle Source: BHF-UCL
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of fibroblast proliferation Source: BHF-UCL
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of glial cell proliferation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of G1/S transition of mitotic cell cycle Source: BHF-UCL
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Spermatogenesis Source: Ensembl
Transcription, DNA-templated Source: UniProtKB

Nucleus

Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation at Ser-364 by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis.
Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by retinoblastoma protein RB1. Regulated by KAP1/TRIM28 which recruits HDAC1 to E2F1 resulting in deacetylation. Acetylated by P/CAF/KAT2B.