EGFLAM

EGFLAM (EGF Like, Fibronectin Type III And Laminin G Domains) is a Protein Coding gene. Diseases associated with EGFLAM include Adiaspiromycosis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and glycosaminoglycan binding. An important paralog of this gene is AGRN.

Full Name

EGF Like, Fibronectin Type III And Laminin G Domains

Research Area

Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity).

Biological Process

Animal organ morphogenesis Source: GO_Central
Extracellular matrix organization Source: Ensembl
Peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
Positive regulation of cell-substrate adhesion Source: Ensembl
Tissue development Source: GO_Central

Cellular Location

Extracellular matrix; Synaptic cleft; Presynaptic active zone. Detected in the synaptic cleft of the ribbon synapse around the postsynaptic terminals of bipolar cells. Colocalizes with BSN, CTBP2 and DAG1 in photoreceptor synaptic terminals.

PTM

O-glycosylated; contains chondroitin sulfate and heparan sulfate.

Anti-EGFLAM antibodies

Mouse Anti-EGFLAM Recombinant Antibody (CBFYE-0544) (CBMAB-E0909-FY)

Datasheet

SDS

Target: EGFLAM

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYE-0544

Application*: E, WB

Mouse Anti-EGFLAM (AA 914-1001) Recombinant Antibody (CBXF-2749) (CBMAB-F3466-CQ)

Datasheet

SDS

Target: EGFLAM

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-2749

Application*: E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)