ESYT1

ESYT1 (Extended Synaptotagmin 1) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include lipid binding and phospholipid binding. An important paralog of this gene is ESYT2.

Extended Synaptotagmin 1

Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity).

Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.

Endoplasmic reticulum-plasma membrane tethering Source: InterPro
Lipid transport Source: UniProtKB-KW

Endoplasmic reticulum membrane; Cell membrane. Localizes primarily to the endoplasmic reticulum (PubMed:29469807). Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:29469807, PubMed:22250200).

Cytoplasmic: 1-38
Helical: 39-59
Lumenal: 60-62
Helical: 63-83
Cytoplasmic: 84-1104

Phosphorylated on Ser residues in insulin-treated adipocytes (in vitro); this promotes interaction with SLC2A4.By similarity