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Mouse Anti-ESYT1 Recombinant Antibody (CBFYE-1316) (CBMAB-E1924-FY)

This product is mouse antibody that recognizes ESYT1. The antibody CBFYE-1316 can be used for immunoassay techniques such as: ELISA, WB, IHC-P.
See all ESYT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1316
Antibody Isotype
IgG2a, κ
Application
ELISA, WB, IHC-P

Basic Information

Immunogen
ESYT2/E-Syt2 antibody was raised against fAM62B full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Extended Synaptotagmin 1
Introduction
ESYT1 (Extended Synaptotagmin 1) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include lipid binding and phospholipid binding. An important paralog of this gene is ESYT2.
Entrez Gene ID
23344
UniProt ID
Q9BSJ8
Alternative Names
Extended Synaptotagmin 1; Family With Sequence Similarity 62 (C2 Domain Containing), Member A; Membrane-Bound C2 Domain-Containing Protein; FAM62A; MBC2; Extended Synaptotagmin-Like Protein 1
Research Area
Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity).

Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.
Biological Process
Endoplasmic reticulum-plasma membrane tethering Source: InterPro
Lipid transport Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane; Cell membrane. Localizes primarily to the endoplasmic reticulum (PubMed:29469807). Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:29469807, PubMed:22250200).
Topology
Cytoplasmic: 1-38
Helical: 39-59
Lumenal: 60-62
Helical: 63-83
Cytoplasmic: 84-1104
PTM
Phosphorylated on Ser residues in insulin-treated adipocytes (in vitro); this promotes interaction with SLC2A4.By similarity
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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