FAM120A

FAM120A (Family With Sequence Similarity 120A) is a Protein Coding gene. Diseases associated with FAM120A include Myiasis and Retinitis Pigmentosa 59. An important paralog of this gene is FAM120C.

Family With Sequence Similarity 120A

May participate in mRNA transport in the cytoplasm (By similarity).

Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses.

Cell membrane; Cytoplasm. Translocates to plasma membrane upon ultraviolet exposure.

Arg-982 is dimethylated, probably to asymmetric dimethylarginine.
Phosphorylated on tyrosine by src family kinases upon ultraviolet exposure.