Recombinant Mouse Anti-FAM120A Antibody (CBAb103) (CBMAB-Ab103-LY)

The product is antibody recognizes FAM120A. The antibody CBAb103 immunoassay techniques such as: WB 1:500-1:1000; IHC 1:20-1:50; IF 1:20-1:50.
See all FAM120A antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBAb103

Antibody Isotype

IgG

Application

WB 1:500-1:1000; IHC 1:20-1:50; IF 1:20-1:50

Basic Information

Immunogen

A synthetic peptide of human FAM120A

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Family With Sequence Similarity 120A

Entrez Gene ID

23196

UniProt ID

Q9NZB2

Alternative Names

FAM120A; C9orf10; HBVPTPAP; OSSA; DNAPTP1; DNAPTP5; family with sequence similarity 120A

Research Area

May participate in mRNA transport in the cytoplasm (By similarity).

Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses.

Cellular Location

Cell membrane; Cytoplasm. Translocates to plasma membrane upon ultraviolet exposure.

PTM

Arg-982 is dimethylated, probably to asymmetric dimethylarginine.
Phosphorylated on tyrosine by src family kinases upon ultraviolet exposure.

References

Ma, J., Meng, Q., Zhan, J., Wang, H., Fan, W., Wang, Y., ... & Zheng, F. (2021). Paeoniflorin suppresses rheumatoid arthritis development via modulating the Circ-FAM120A/miR-671-5p/MDM4 axis. Inflammation, 44(6), 2309-2322.

Sun, L., Stucky, A., Tu, L., Chen, X., Luo, J., & Zhong, J. F. (2020). FAM120A-PTPN3 variations in neuroblastoma: Implications for poor prognosis and relapse.

Kelly, T. J., Suzuki, H. I., Zamudio, J. R., Suzuki, M., & Sharp, P. A. (2019). Sequestration of microRNA-mediated target repression by the Ago2-associated RNA-binding protein FAM120A. RNA, 25(10), 1291-1297.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-FAM120A Recombinant Antibody (CBXF-3450)

Mouse Anti-FAM120A Recombinant Antibody (CAP738)

Mouse Anti-FAM120A Recombinant Antibody (CBXF-0271)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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