FAM19A5

FAM19A5 is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to play a role as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells.

Family With Sequence Similarity 19 Member A5, C-C Motif Chemokine Like

Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity).

Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity).

Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity).

Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2 (By similarity).

Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity).

Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (By similarity).

G protein-coupled receptor signaling pathway Source: MGI
Negative regulation of vascular associated smooth muscle cell migration Source: Ensembl
Negative regulation of vascular associated smooth muscle cell proliferation Source: MGI
Negative regulation of vascular wound healing Source: Ensembl

Secreted