FARP2

FARP2 (FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2) is a Protein Coding gene. Among its related pathways are PAK Pathway and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and Rac guanyl-nucleotide exchange factor activity. An important paralog of this gene is FARP1.

FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2

Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).

Actin cytoskeleton reorganization Source: UniProtKB
Cell adhesion Source: UniProtKB
Hair cycle process Source: Ensembl
Neuron remodeling Source: MGI
Osteoclast differentiation Source: UniProtKB
Podosome assembly Source: UniProtKB
Rac protein signal transduction Source: MGI
Regulation of integrin activation Source: UniProtKB
Semaphorin-plexin signaling pathway Source: UniProtKB

Cytoskeleton; Cytosol; Cytoplasm