Rabbit Anti-FARP2 Recombinant Antibody (EG1202) (CBMAB-EN1454-LY)

The product is antibody recognizes FIR. The antibody EG1202 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all FARP2 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse

Clone

EG1202

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from Internal of human FIR.

Specificity

Human, Mouse

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2

Entrez Gene ID

Human	9855
Mouse	227377

UniProt ID

Human	O94887
Mouse	Q91VS8

Research Area

Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).

Biological Process

Actin cytoskeleton reorganization Source: UniProtKB
Cell adhesion Source: UniProtKB
Hair cycle process Source: Ensembl
Neuron remodeling Source: MGI
Osteoclast differentiation Source: UniProtKB
Podosome assembly Source: UniProtKB
Rac protein signal transduction Source: MGI
Regulation of integrin activation Source: UniProtKB
Semaphorin-plexin signaling pathway Source: UniProtKB

Cellular Location

Cytoskeleton; Cytosol; Cytoplasm

References

Danelon, V., Goldner, R., Martinez, E., Gokhman, I., Wang, K., Yaron, A., & Tran, T. S. (2020). Modular and distinct plexin-A4/FARP2/Rac1 signaling controls dendrite morphogenesis. Journal of Neuroscience, 40(28), 5413-5430.

Elbediwy, A., Zhang, Y., Cobbaut, M., Riou, P., Tan, R. S., Roberts, S. K., ... & Parker, P. J. (2019). The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity. Journal of cell science, 132(8), jcs223743.

Sahin, M., & El, H. (2018). External validation and evaluation of reliability of the FARP2 score to predict early graft failure after infrainguinal bypass. Annals of Vascular Surgery, 51, 72-77.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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