FBXO4

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq]

Full Name

F-box protein 4

Research Area

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.

Biological Process

Aging Source: Ensembl
Cellular homeostasis Source: Ensembl
Cellular response to ionizing radiation Source: Ensembl
Common myeloid progenitor cell proliferation Source: Ensembl
Negative regulation of fibroblast proliferation Source: Ensembl
Negative regulation of protein localization to nucleus Source: Ensembl
Positive regulation of protein polyubiquitination Source: Ensembl
Positive regulation of protein ubiquitination Source: BHF-UCL
Positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Posttranscriptional regulation of gene expression Source: Ensembl
Protein destabilization Source: Ensembl
Protein polyubiquitination Source: UniProtKB
Protein ubiquitination Source: UniProtKB
Regulation of DNA damage checkpoint Source: Ensembl
Regulation of protein stability Source: BHF-UCL
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Telomere maintenance Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: UniProtKB

Cellular Location

Cytoplasm

PTM

Phosphorylation at Ser-12 varies during the cell cycle. It is low in resting cells and high in the S phase and the G2/M phase of the cell cycle. Phosphorylation is decreased during late G1 phase (By similarity). Phosphorylation at Ser-12 promotes homodimerization and is necessary for optimal ubiquitin ligase activity towards CCND1.